Ansaid

A nonsteroidal anti-inflammatory drug (NSAID) is Ansaid (flurbiprofen). Flurbiprofen works by lowering hormones in the body that lead to pain and inflammation. Ansaid is used to treat pain or inflammation brought on by gout, arthritis, tendinitis, bursitis, ankylosing spondylitis, or menstrual cramps. Ansaid can be used for additional conditions not covered in this medication guide. If you are allergic to flurbiprofen or any other NSAID (such as naproxen, ibuprofen, celecoxib, diclofenac, indomethacin, meloxicam, and others), you shouldn't use Ansaid.

Inform your doctor of any of the following to ensure that Ansaid is safe for you:

• kidney illness
• liver illness
• Congestive heart failure, heart disease, or high blood pressure
• other breathing disorders, such as asthma
• swollen or retained fluid
• an issue with bleeding or blood clotting
• peptic ulcers
• Inflammatory colitis
• Crohn's illness

Whether this medication will harm an unborn child is unknown. If you are pregnant or intend to become pregnant, let your doctor know. At any point during treatment, NSAIDs can lead to stomach and intestine bleeding and ulcers. If you regularly take Ansaid, your doctor will want to review your progress when you see him or her. To check for unintended effects, your blood and urine may be tested.

Pharmacokinetics

The gastrointestinal tract quickly absorbs ansaid, and peak plasma concentrations happen 1 to 2 hours after administration. Ansaid has a bioavailability of about 100%.

99% of Ansaid's plasma protein binding is to albumin.

Cytochrome P450 enzymes, particularly CYP2C9, metabolize flurbiprofen in the liver to create a number of metabolites, the two most important of which are 5-hydroxyflurbiprofen and 3′-hydroxyflurbiprofen.

Flurbiprofen has an elimination half-life of 1.3 to 4 hours.

As metabolites and conjugates, ansaid is eliminated in the urine. The amount of flurbiprofen that remains unchanged in the urine after administration is less than 1%.

Side Effects

Ansaid side effects could include:

• Dizziness,
• Drowsiness,
• Headache,
• Nervousness,
• Stomach pain,
• Heartburn,
• Gas,
• Bloating,
• Constipation, or diarrhea,
• Ringing in the ears
• Skin rash or itching,
• Swelling in the hands or feet,
• White patches or sores inside the mouth or on the lips.

If you experience any of the following:

• Swelling, breathlessness (even with light exertion), and rapid weight gain
• Jaundice (yellowing of the skin or eyes), dark urine, clay-colored stools, itching, nausea, and upper stomach pain
• Bloody or tarry stools, bloody or coffee-ground-looking vomit, or bloody or tarry coughing
• Bruising, intense tingling, numbness, pain, and weakness of the muscles
• The first signs of a skin rash, such as itching, red, swollen, blistered, or peeling skin with or without a fever, are indicative of stomach bleeding.
• Other symptoms include severe upper stomach pain that radiates to your back, nausea, vomiting, and a rapid heartbeat.

DOSAGE AND ADMINISTRATION

Ansaid Tablets should be taken daily in doses of 100 to 200 mg. According to each patient's unique treatment objectives, patients should receive the lowest effective dosage for the shortest amount of time (see WARNINGS).

If you experience nausea, drink milk or eat food first.

The typical adult dosage for treating rheumatoid arthritis is 100 to 200 mg daily in divided doses.

The typical adult dosage for osteoarthritis relief is 100 to 200 mg daily in divided doses.

The typical adult dosage for menstrual cramp relief is 50 to 100 mg per day.

Indications and Usage

Ansaid is prescribed to treat the symptoms of osteoarthritis and rheumatoid arthritis.

Overdose

An overdose of Ansaid is unlikely to result in symptoms that could be fatal. In the event of an overdose, stop taking the medication, treat symptoms, and put supportive measures in place. Monitoring of the fluid and electrolyte balance is necessary.

Storage

Store at 68° to 77°F (20° to 25°C) Please refer to USP Controlled Room Temperature.] Defend against moisture. As specified in the USP/NF, dispense in a tightly sealed, light-resistant container.