2DG

2DG, or 2-Deoxy-D-glucose, is a glucose analog that plays a key role in cancer therapy and metabolic research. As a glycolytic inhibitor, 2DG mimics glucose but cannot be metabolized, effectively starving energy-dependent cancer cells by blocking glycolysis, their primary energy pathway. This unique mechanism allows 2DG to selectively target tumor cells, making them more susceptible to other cancer treatments such as chemotherapy and radiotherapy.

In addition to its promising role in oncology, 2DG has gained attention for its potential to modulate metabolic pathways, offering benefits for conditions such as viral infections and neurodegenerative diseases. Studies have shown that 2DG may help reduce inflammation, slow down the progression of Alzheimer's, and improve mitochondrial function by reducing oxidative stress.