Cylert

A central nervous system stimulant of the amphetamine class called Cylert (pemolin) is used to treat ADD and narcolepsy. It was taken off the US market in 2005 as a result of declining sales brought on by worries about liver toxicity.

Health Benefits

The effectiveness of Cylert in treating narcolepsy and attention deficit disorder (ADD) has been established.

The efficacy of amphetamines, such as Cylert, has also been demonstrated in a number of tasks requiring sustained attention and vigilance, working memory, and executive function.

Amphetamines have also been demonstrated to improve alertness and lessen fatigue.

Possible Side Effects

The most frequent negative effects of Cylert include:

nausea

vomiting

diarrhea

abdominal pain

reduced appetite

slim down

headache

dizziness

shaking or tremors in the hands or feet

anxiety

nervousness

restlessness

insomnia

mouth ache

sweating

modifications to sex ability or drive.

uncommon negative effects include:

seizures

psychotic symptoms

hallucinations

hostile or combative behavior

confusion

paranoia.

Serious negative effects consist of:

chest pain

stroke

sudden demise

chest pain from angina gets worse

blood pressure rising

Dosages

Adults with attention deficit disorder typically start Cylert at a daily dose of 18.75 mg.

Every week, the dose may be raised by 18.75 mg until the desired response is obtained or side effects are an issue.

The typical starting dose for narcolepsy is 37.5 mg per day.

Every week, the dose can be raised by 37.5 mg to see if the desired response is obtained or if side effects start to be an issue.

It is best to take Cylert with food to reduce stomach discomfort.

Cylert should be taken exactly as directed; skipping doses or stopping suddenly can result in withdrawal symptoms like fatigue, depression, and irritability.

Interactions

Cylert should not be taken in conjunction with monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants due to potential drug interactions.

Additionally, it may interact with other CNS stimulants, raising the possibility of adverse effects like agitation, anxiety, headache, nausea, and insomnia.

Cylert should be used cautiously in patients with liver disease because it can interact with a number of drugs that have an impact on liver function.

Tell your doctor about all other medications you are taking, including over-the-counter remedies, vitamins, and herbal supplements, if you are taking Cylert.

Mechanism of Action

The way Cylert works is by raising the brain's dopamine and norepinephrine levels.

These neurotransmitters play a role in the control of cognitive processes like learning and attention.

Serotonin levels are slightly impacted by Cylert as well.

Pharmacokinetics

Cylert is quickly absorbed from the digestive system and reaches its peak blood levels in 2–3 hours.

Its half-life is between 10 and 12 hours.

A dose taken orally is only partially unchangedly excreted in urine, about 5%.

The liver metabolizes the majority of the drug, which is then excreted as inactive metabolites in the urine.

Conclusion A central nervous system stimulant called Cylert is used to treat narcolepsy and attention deficit disorder (ADD). There are many potential side effects, some of which can be severe. In patients with liver disease or other medical conditions, it should be used cautiously.

Alternatives to Cylert

Other drugs, such as the following, can be used to treat narcolepsy and attention deficit disorder, including:

Adderall

Ritalin

Vyvanse

Concerta

Strattera

Provigil

Nuvigil.

Clinical Trials

For the treatment of attention deficit disorder, Cylert has undergone two FDA-conducted clinical trials.

With a decrease in ADD symptoms like restlessness, impulsivity, and hyperactivity, Cylert was shown to be effective in both trials.

These trials' most frequent side effects included nausea, appetite loss, weight loss, headaches, and insomnia.

Narcolepsy treatment with Cylert has also been investigated.

In a small trial, it was shown that Cylert helped narcoleptic patients feel better and experience less daytime sleepiness.

In a different trial, it was discovered that Cylert reduced narcoleptic patients' sleep latency—the amount of time it takes for them to fall asleep.

In these trials, insomnia, headaches, and gastrointestinal discomfort were the most frequently reported side effects.