A barbiturate with a long half-life is phenobarbital. It serves as a sedative and anticonvulsant. This article is meant to provide users of Welzo with information about phenobarbital.

Health Benefits

There are several potential health advantages of phenobarbital, including:

1. Phenobarbital is frequently prescribed for the treatment of epilepsy and other seizure disorders. It functions by reducing the activity of brain nerve cells.

2. reducing anxiety: Phenobarbital can ease tension and reduce anxiety.

3. bringing on sleep: Phenobarbital is frequently employed as a sedative to bring on sleep.

4. Relieving pain: Phenobarbital is effective at reducing pain, especially when combined with other analgesics.

Phenobarbital is another medication that can help to lower fever.

Side Effects

Phenobarbital's most frequent adverse reactions are drowsiness, lightheadedness, nausea, vomiting, loss of coordination, and blurred vision.Depression, memory or thinking problems, and movement issues are some of the more severe side effects that could occur.


The individual and the condition being treated will determine the phenobarbital dosage that should be used.The typical starting dose for epilepsy is 15 mg/kg per day, split into 2 or 3 doses.The typical dose for insomnia is 100–200 mg taken before bed.


Other medications and dietary supplements, such as alcohol, barbiturates, benzodiazepines, cimetidine, MAO inhibitors, and warfarin, may interact with phenobarbital.

Alcohol and other drugs that depress the central nervous system shouldn't be combined with phenobarbital. These substances increase the likelihood of respiratory depression and potentiate the sedative effects of phenobarbital.

The blood concentrations of phenobarbital can rise when taking cimetidine. This could intensify phenobarbital's sedative effects and raise the possibility of negative side effects.

Phenobarbital and MAO inhibitors can interact, raising the possibility of adverse effects.

Blood thinner warfarin (Coumadin) and phenobarbital may interact. Warfarin levels in the blood can rise due to phenobarbital, which could lead to an increased risk of bleeding.

Mechanism of Action

Phenobarbital affects the central nervous system to produce its effects.It accomplishes this by attaching to the GABA receptor, a particular receptor in the brain.GABA, a neurotransmitter that inhibits the activity of nerve cells, becomes more active as a result of this.Phenobarbital can therefore help to lessen seizures and induce sleep.


Phenobarbital is quickly absorbed from the digestive system and reaches its peak blood levels in 1 to 2 hours.Then it is broken down in the liver and eliminated in the urine.Phenobarbital has a half-life of 36 to 72 hours.