Tigan

What is Tigan?

An antiemetic medication called Tigan (trimethobenzamide) is used to treat nausea and vomiting. It functions by obstructing serotonin, a natural chemical your body produces when you vomit.

The generic version of tigan is offered. Drugs that are generic typically cost less than those that are brand-name. They might not always be offered in every strength or form that the brand-name medication is.

Health Benefits

Tigan is used to treat nausea and vomiting brought on by specific conditions (like cancer, chemotherapy, and radiation treatment). Additionally, it can be used to stop the recurrence of these conditions during or after treatment.

Other uses for tigan not covered in this medication guide are also possible.

Side Effects

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

If you experience any of the following:


convulsions (seizures);

a feeling of impending faintness or lightheadedness;

urinating either infrequently or not at all;

jaundice (a skin or eye yellowing);

upper stomach pain, nausea, and vomiting (which could radiate to your back);

rapid or pounding heartbeats, chest fluttering, shortness of breath, and an unexpected feeling of vertigo;

any of the following symptoms: agitation, hallucinations, fever, sweating, confusion, rapid heartbeat, loss of coordination, nausea, vomiting, or diarrhea;

Typical negative effects could be:

drowsiness;

headache;

drowsiness; or

a slight constipation.

There may be additional side effects; this is not a comprehensive list. For medical advice about side effects, contact your doctor.

Dosage

Adults typically take 50 to 100 mg three or four times per day. The maximum daily dose advised is 400 mg.

The typical dose is 5 to 10 mg/kg (or 2.3 to 4.5 mg per pound) administered 3 or 4 times per day to children 2 years of age and older. The maximum daily dose advised is 40 mg/kg.

Interactions

At each of your routine checkups, especially in the initial weeks after starting this medication, your doctor should assess your progress. The need for blood tests to check for side effects may arise.

Other drugs can influence how well Tigan functions, and other drugs can influence how well Tigan functions. Inform all of your healthcare professionals about every medication you are currently taking as well as any that you begin or stop using.

Mechanism of Action

The antiemetic action of this drug is not completely understood, but may be due to its central inhibitory effect on the chemoreceptor trigger zone or vomiting center in the medulla oblongata. In dogs and cats, trimethobenzamide inhibits emesis induced by apomorphine, xylazine, glucagon, and cisplatin. In humans, it inhibits emesis induced by chemotherapy agents.

Pharmacokinetics

Following oral administration, trimethobenzamide is quickly and almost completely absorbed. About 65% of it is bioavailable. Only traces of the unchanged drug are detected in the urine because it undergoes extensive first-pass metabolism in the liver. About 3 hours pass during the plasma half-life.

Protein binding has little impact. The blood-brain barrier is crossed by trimethobenzamide, which is widely distributed throughout the body. Trimethobenzamide may or may not be excreted in human milk.

Alternatives to Tigan

The same active ingredient (trimethobenzamide) is also present in the following medications:

Stugeron

Taniela Forte

Tablets for Motion Sickness

Other medications that treat nausea and vomiting are widely available. Some might work for you better than others. Consult your doctor about any additional options that might be suitable for you.

Tigan and Alcohol

Alcohol consumption should be avoided while taking Tigan. Alcohol can increase the risk of side effects, including drowsiness and low blood pressure.