Lidex
Drug Interactions
Lidex and other medications may interact with one another. All of the prescription and non-prescription medications you take should be disclosed to your doctor. This includes medicines prescribed by other doctors as well as vitamins, minerals, and herbal products. Never begin taking a new medication without first consulting your physician. Utilizing Lidex: As prescribed by your doctor, use Lidex. For precise dosing recommendations, refer to the medication's label. With Lidex, an additional patient leaflet is available. If you have any questions about this information, speak with your pharmacist. Before using, wash and dry your hands.
Apply a thin layer of medicine and gently rub it into the affected area. Applying to broken, irritated, or red skin is not advised. Application to the face, underarms, or groin should only be done under a doctor's direction. If you are using Lidex cream, avoid using a bandage or other covering on the treated skin area unless your doctor instructs you to. You can wrap a bandage made of fresh cotton gauze over the treated skin area if you're using Lidex lotion. Apply not to open wounds. Avoid getting this medication in your eyes if applying near the eyes because doing so could exacerbate or even start glaucoma.
Additionally, avoid getting this medicine in your mouth or nose. If medication does get into these areas, flush it out thoroughly with water. Lidex should be used consistently if you want to reap its benefits. You'll be more likely to remember to use Lidex if you use it every day at the same time. Lidex should be used until your doctor instructs you to stop. Avoid making contact with people who are contagious (such as those who have the flu, measles, or chickenpox). If you have been exposed to an infection or would like more information, speak with your doctor. Do not consume it orally. Only the skin may be used to apply topical medications. Do not use this medicine on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. If this medicine gets in your eyes, nose, mouth, rectum, or vagina; rinse with water. Do not apply other skin products on the areas you treat with Lidex unless directed by your doctor.
Pharmacokinetics
Absorption:
Cream and ointments: Topical application results in negligible fluocinonide absorption. Application occlusive dressings or plastic wraps further reduces systemic absorption.
After topical application, lotion has very little systemic absorption.
Excretion and Metabolism:
liver-mediated metabolism results in inactive metabolites that are excreted in urine. Beginning of Action: Topical: Ointment lasts 6–8 hours; cream and lotion, 1-2 hours. Action lasts for a topical maximum of 24 hours.
Serum has a 6- to 8-hour half-life.
>99% Protein Binding
Cream and ointment with fluocinonide USP, 0.05% contain:
In an ointment base made up of mineral oil and white petrolatum, the active ingredient fluocinonide is combined with cetyl alcohol, cyclomethicone, glycerin, glyceryl monostearate SE, polysorbate 60, propylene glycol, and sorbitan stearate. Additionally, benzyl alcohol and trolamine are in the fluocinonide cream's list of inactive ingredients. Ceresin wax and lanolin alcohols are additional ingredients in fluocinonide ointment.
pharmaceutical practice
A highly potent synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties is called fluocinonide.
When given systemically at relatively low dosage levels to laboratory animals, corticosteroids have been demonstrated to be teratogenic. Following dermal administration to laboratory animals, some corticosteroids have been demonstrated to be teratogenic.
The effects of topically applied corticosteroids on teratogenicity have not been adequately and carefully studied in pregnant women. Since there may be risks to the fetus, topical corticosteroids should only be used during pregnancy if the potential benefit outweighs those risks.
Side Effects
The most frequently reported negative effects include skin dryness, burning, itching, and irritation. Most of the time, these side effects are minor and therapy can continue despite them.
Fluocinonide cream and ointment USP, 0.05% are provided in 15 g tubes, are white to off-white in color, and have a smooth texture.
Fluocinonide lotion USP, 0.05% is available in 60 mL bottles and is a colorless to light yellow solution.
Do not consume it orally. Only the skin may be used to apply topical medications. This medication should not be applied to open wounds, sunburned, windburned, dry, chapped, or inflamed skin. Rinse with water if this medication spills into your eyes, nose, mouth, rectum, or vagina.
Avoid using additional skin care products on the treated areas.
Dosage and Administration
The typical dosage is
Adults and children aged 12 and over—
Depending on how severe the condition is, apply a thin layer of cream or ointment to the affected area 2 to 4 times per day. If an infection starts to spread, the proper antimicrobial therapy needs to be started. Reduce the frequency of application to once or twice per day as maintenance therapy once the condition has improved.
Overdose
There haven't been any reports of topical fluocinonide overdoses.
only for external use. Avoid coming into contact with the vagina, rectum, mouth, nose, or eyes. If this happens, give yourself a good water rinse. If irritation occurs, stop using the product and start the recommended therapy. Before using, consult a health care provider if you are pregnant or nursing.
If you accidentally ate something, get medical help right away or call a poison control center.
Storage
See USP Controlled Room Temperature for storage recommendations of 20° to 25°C (68° to 77°F). Defend against freezing.