A headache medication called Migranal (dihydroergotamine mesylate) constricts the blood vessels surrounding the brain. Migranal is used to treat headaches, aura or not.Other uses for Migranal aside from those in this medication guide are possible.

Health Benefits

Migranal can assist in alleviating migraine symptoms such as pain, nausea, and sensitivity to light and sound. This drug may also aid in preventing migraines from happening.

Migranal is a medication that must be obtained by prescription and is not sold over-the-counter (OTC). It comes as an injection, and a healthcare professional typically administers it.

An already existing headache should not be treated with migrain. Only future migraines or the symptoms of an aura, which are warning signs that a migraine is about to happen, should be treated with it.

Side Effects

The following are typical Migranal side effects:drowsiness,dizziness,nausea,vomiting,diarrhea,stomach cramps or painfeeling flushed (warm, red, or tingly), and/orheadaches.Serious negative effects of migranal include:stroke,cardiac arrest, orbleeding clots.In the event that you encounter any of these severe side effects, contact your doctor right away.


2-4mg of Migranal should be injected under the skin once daily to prevent migraines.At the first sign of a migraine, an injection under the skin of 6–9 mg is advised for treatment.After 30 minutes, a second dose may be given, if necessary.A 24-hour period should not see more than two uses of Migranal.


It's possible for Migranal to interact with the following drugs:

SSRIs, or selective serotonin reuptake inhibitors,

either triptans or

Alkaloids in ergot.

Any medication you take should be disclosed to your doctor. When pregnant, migranal shouldn't be used unless the advantages outweigh the risks. This medication may enter breast milk and negatively impact a nursing infant. Before breastfeeding, speak with your doctor.

Migranal is not advised for use by those with the following medical conditions:

cardiovascular disease,

uncontrolled hypertension,

a history of blood clots or stroke,

heart attack history, or

disease of the peripheral vessels.

You might not be a good candidate for Migranal if you have certain medical conditions. Tell your doctor right away if you experience any additional health issues, especially:

allergy or asthma,



high blood pressure,

history of heart disease or heart attack,

history of stroke or blood clot, or

kidney disease.

Mechanism of Action

Migranal causes the blood vessels surrounding the brain to constrict. This action lessens the migraine-related discomfort, motion sickness, and sensitivity to light and sound.

Migranal may also aid in the prevention of migraines. The exact mechanism by which this drug prevents migraines is unclear.


Migranal has a 15-minute time window for starting to work after being quickly absorbed from the injection site. Within one to two hours, the effect peaks.

The liver breaks down migrane, which is then eliminated in the urine.

3–4 hour half-life

95% protein binding

0.85 L/kg of distribution volume

7.7 mL/min/kg of clearance