A catechol-o-methyltransferase (COMT) inhibitor called Tasmar (generic name: tolcapone) is used as an adjunctive therapy for Parkinson's disease. Dopamine is one of the catecholamines that are broken down by the enzyme COMT. Dopamine levels in the brain rise as a result of COMT inhibition.Tasmar is frequently combined with another Parkinson's disease medication, levodopa/carbidopa. Tasmar can help with Parkinson's disease symptoms, but it cannot treat the illness.Users of Welzo can use this article for informational purposes to better understand Tasmar.

Health Benefits

It has been demonstrated that Tasmar works well to reduce Parkinson's disease symptoms. Clinical tests on Tasmar have revealed that it:

- Enhance motor performance

Reduce "off" time (times when a patient's symptoms get worse and their medication isn't working as well).

- Decrease dyskinesia (uncontrollable movement)

Patients with Parkinson's disease may experience a higher quality of life after taking tasmar. Patients who took Tasmar in one study reported improvements in daily living activities like dressing, bathing, eating, and using the restroom. Additionally, they noted improvements in their mood and cognitive abilities.

Side Effects

Tasmar's most typical side effects include:

- Diarrhea

- Vertigo

- Vomiting

- Migraine

- Weakness

Additionally, Tasmar can result in uncontrollable movements (dyskinesia), especially when the dosage is first started or raised. When the dose is decreased or given more time, these movements typically stop.

Tasmar side effects that are less frequent include:

- Suicidality

A hallucination

- Perplexity

Tasmar's uncommon side effects include: - Liver damage - Blood conditions - Allergy symptoms Stop taking Tasmar right away if you experience any of these severe side effects and call your doctor right away.


Tasmar is typically started at a dose of 25 mg once daily. Up to a daily dose of 200 mg, your doctor may increase your dose every two weeks by 25 mg.

Take Tasmar before going to bed. Taking it with or without food is acceptable.

Take the missed Tasmar dose as soon as you remember it if you do. Skip the missed dose and carry on with your regular dosing schedule if it is almost time for your next dose. Never take two Tasmar doses at the same time.


It is crucial to inform your doctor about all the medications you are taking, including over-the-counter medicines, vitamins, and herbal supplements, as Tasmar may interact with a variety of other drugs.

Tasmar frequently has interactions with the following drugs:

- MAOIs, or monoamine oxidase inhibitors

- Cholinergic blockers

- Psychostimulants

- Emetic drugs

- Narcotics

- Anesthetics

It's crucial to let your doctor know about all of the medicines you're taking, including over-the-counter medicines, vitamins, and herbal supplements, as Tasmar can interact with a variety of other drugs.

Do not take any additional medications while taking Tasmar without first consulting your doctor.


Tasmar is quickly absorbed from the digestive system and reaches its peak blood levels in 1-2 hours. Tasmar has a half-life of around two hours.

The CYP3A4 enzyme helps the liver process Tasmar. Therefore, medications that activate or inhibit this enzyme may have an impact on the blood levels of Tasmar.

Tasmar is primarily excreted from the body through urine.

Alternatives to Tasmar

Other medicines, such as the following, can be used to treat Parkinson's disease:

- Carbidopa/Levodopa

- Agonists of dopamine


- Cholinergic blockers

Your doctor can advise you on the best treatment option for your particular circumstances.