Following oral administration, ceftin is quickly and entirely absorbed. Following a 500 mg dose, the mean peak serum concentration (Cmax) is attained 1 to 2 hours later. The 250 mg tablet has a bioavailability of roughly 50%, while the 125 mg/5 mL suspension has a bioavailability of roughly 74%.

Following a single 500 mg dose, the serum half-life in adults ranges from 1.4 to 2.6 hours. Following a single 25 to 50 mg/kg dose in children, the serum half-life has been reported to range from 1.3 to 3.8 hours.