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Differin Gel
Differin Cream
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Differin - welzo
Differin Gel
Differin Cream
Differin - welzo
Differin - welzo
Nathalie Hayek reviewed
"Customer service was quick to respond and medication arrived the very next day!"
Anthony Limasol reviewed
"Quick, fast and reliable service. Use Welzo monthly for my medication."
Remeece Freeman reviewed
"No fuss, and fast delivery. Welzo dispatched my order the same day and it arrived in the morning."


Differin Gel
Differin Cream
Differin - welzo
Differin - welzo
Differin Gel
Differin Cream
Differin - welzo
Differin - welzo
Nathalie Hayek reviewed
"Customer service was quick to respond and medication arrived the very next day!"
Anthony Limasol reviewed
"Quick, fast and reliable service. Use Welzo monthly for my medication."
Remeece Freeman reviewed
"No fuss, and fast delivery. Welzo dispatched my order the same day and it arrived in the morning."
16 Reviews
In stock.
16 Reviews

Differin is a fragrance-free topical retinoid treatment for acne. It is available in cream and gel form....

Differin is a fragrance-free topical retinoid treatment for acne. It is available in cream and gel form. It contains Adapalene 0.1% which regulates the skin cell turnover closer to its natural rate, helping the pores from getting clogged.  

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Pricing is provided as a reference. Treatment will be shown after completing the consultation. The final decision on issuing this medication remains with the prescriber.
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Nathalie Hayek reviewed
"Customer service was quick to respond and medication arrived the very next day!"
Anthony Limasol reviewed
"Quick, fast and reliable service. Use Welzo monthly for my medication."
Remeece Freeman reviewed
"No fuss, and fast delivery. Welzo dispatched my order the same day and it arrived in the morning."
As seen in
The_Daily_Mirror_logo - welzo
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Description of Differin

What is Differin?

Differin is a topical medication that comes as both a gel and a cream that treats acne vulgaris and other skin conditions.

How does it work?

Differin contains the active ingredient adapalene 0.1% which is a form of vitamin A. Adapalene reduces the growth of keratin skin cells that would normally block pores as seen in the acne vulgaris condition. Adapalene also regulates the turnover of skin cells which contributes to reducing the pores getting clogged.

Is Differin right for me?

Differin is used to treat acne and as a topical treatment and it is a great alternative for those who cannot or do not wish to take oral medications. It reduces the number of whiteheads, blackheads and pustules on the skin so it's an effective treatment for mild to moderate acute acne.

However, Differin may not be suitable if the following applies:

  • If you are pregnant or planning to become pregnant
  • If you are allergic to Adapalene or any of its ingredients

The product images shown may represent the range of products, or be for illustration purposes only and may not be an exact representation of the product.

Dosage of Differin

Commonly Used Dosage Guidelines for Differin

For cream and gel: apply to clean and dry skin. Apply thinly at bedtime to affected areas. Wash hands after use.

  • DO NOT use Differin on areas where you have cuts or scrapes or if you have a skin condition called eczema.
  • Avoid contact with the eyes, mouth, or nostrils, and avoid other very sensitive areas of the body. If accidental contact does occur, immediately wash with warm water.
  • Avoid exposure to sunlight and artificial UV light whilst using Differin.

Disclaimer: This website does not provide medical advice.No information listed on this website is intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment before undergoing a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Side Effects of Differin

All medications can cause potential side effects, below we have listed some potential side effects, however, these do not always occur.

  • A burning, stinging or tingling feeling
  • Dry skin
  • Itching or redness
  • A rash

Disclaimer: This website does not constitute as medical advice, you should also consult with a doctor before taking medication. If you experience any major reactions to any medication you are taking, you must seek immediate medical attention.


Next Day Delivery Guarantee

All orders placed before 14:00 weekdays will be delivered the next working day. For the majority of the UK, medication will be dispatched by Royal Mail, Monday to Friday, if ordered before 14:00. Dispatches are sent using Royal Mail's Next-Day Tracked 24 Hour service. We will email you tracking information directly and you should receive your order the day after dispatch.

Our Discreet Packaging Promise

We know that many of our customers turn to us when they need personal medication, preferring to use our online service rather than shopping for the product face to face. That is why our delivery is always discreetly packaged in plain brown boxes or envelopes. You will not have to worry about any content descriptions, and the package will be for your eyes only!

Differin Reviews

Differin is an effective treatment, but it might not work for all patients. Find out a comprehensive list of reviews on Differin below taken from independent sources.

Read review on Differin below:

  • Differin has a rating of 6 out of 10 for acne treatment according to user reviews on
  • Patients who have used have rated us “excellent” on Trustpilot. We have over 20,000+ reviews from multiple platforms, click here to view our Trustpilot reviews and click here to read our reviews on Trustindex.

How to use Differin?

Always use Differin exactly as prescribed by your doctor or as advised by the pharmacist. 

Differin use is not recommended for children under 12 years of age. 

  • Wash and dry your skin thoroughly and apply a thin layer of Differin on the affected area.
  • After using Differin, wash your hands properly. Avoid getting the gel around or in the eyes, mouth and nose. 
  • Apply Differin once a day before bed, or as instructed by your provider.
  • After using the gel for 3 months, check with your doctor to measure the improvement and get advice on treatment.
  • While using Differin, avoid direct exposure to artificial UV light or sunlight. 

If unsure of how to use Differin or if you have further questions, please consult your doctor or pharmacist.

Warning and Precautions of Differin

Differin may not be safe if used with certain medications or recreational drugs. Please inform the prescriber if you are taking any of the listed medications.

DO NOT use Differin:

  • If you are using other products for acne containing clindamycin, erythromycin or benzoyl peroxide, they may be used in the morning while using Differin at night. Please consult with your provider.
  • If you are using cosmetics that cause dry skin or blackheads.

The above-listed warnings are not exhaustive, please consult a doctor, pharmacist or nurse if you have further questions on the use of this medication or potential interactions with other medicines.

Additional Information

Differin is available as both a cream and gel.

It works to clear and prevent the symptoms of acne by using the ingredient adapalene which is a type of retinoid. Retinoids can help to regulate cell turnover which can prevent the pores from becoming clogged and forming acne.

Product reviews

Complete a Quick & Free Online Consultation

This is a quick process and should only take 1 - 2 minutes. All of your answers are confidential, and just like a GP consultation, you will know what treatment is most suitable for you instantly upon completion.

Place Your Order for Differin

Once you have completed the quick online form, select the treatment option most suitable to you and checkout securely.

Express Next Day Delivery

A medical professional will review your answers to the online medical consultation and determine if it’s safe to prescribe and what treatments are available.

General Information

What does Differin actually do?

Differin, with its active ingredient adapalene, is a type of retinoid used for the treatment of acne. It works by promoting skin cell turnover, thereby preventing the formation of acne and promoting the healing of existing acne. It has anti-inflammatory effects which help to reduce redness and swelling associated with acne.

Is Differin Gel the same as retinol?

No, although Differin and retinol are both types of retinoids, they are not the same thing. Differin contains adapalene, which is a type of retinoid that is different from retinol. Adapalene is generally less irritating than retinol and is specifically formulated to treat acne.

Is Differin better than a retinol?

Whether Differin or retinol is better largely depends on the user and the reason they are using the product for. Differin (adapalene) is generally considered superior for treating acne because it's more effective at unblocking pores and has potent anti-inflammatory effects. Retinol, on the other hand, is often used for its anti-ageing benefits, like reducing the appearance of fine lines and wrinkles, improving skin texture, and promoting a brighter complexion.

Dosage & Usage

Is Differin Gel good to use everyday?

Yes, Differin Gel is typically applied once daily, usually at bedtime. However, a healthcare provider is able to better advise on how to use it based on the individual skin type and condition.

Which should I use: Differin cream or gel?

Differin is available in both cream and gel forms. Both contain the same active ingredient, adapalene. The choice between the two often depends on personal preference and skin type. The gel might be more suitable for those with oily skin, while the cream might be better for those with dry skin.

Can I wear makeup with Differin?

Yes, a Differin user is able to wear makeup while using the product. However, it's important to apply Differin on clean, dry skin before applying makeup. Be sure to choose non-comedogenic makeup that won't clog the pores and make acne worse.

Do I have to use Differin at night?

Yes, Differin is typically applied once daily, usually at bedtime. The reason is that it potentially makes the skin more sensitive to the sun. However, one must follow a healthcare provider's instructions.

How long should I use Differin for?

Improvement in acne is usually seen after 8 to 12 weeks of treatment with Differin. However, treatment regimens vary based on individual needs, so it's important to discuss the situation with a healthcare provider.

Availability & Pricing

Is Differin sold in the UK?

Yes, Differin is available in the UK. It is available for purchase with a prescription from a healthcare provider.

Alternatives & Related Treatments

What is a dupe for Differin Gel?

There aren't exact "dupes" for Differin Gel, as adapalene is a unique type of retinoid. However, other over-the-counter acne treatments containing different active ingredients, such as benzoyl peroxide or salicylic acid, are potentially effective. If one is looking for another over-the-counter retinoid, retinol is a product to consider. However, these are generally less potent and might not be as effective for treating acne. Consult with a doctor on the best option. 

Side Effects & Considerations

Differin isn't working - what now?

If an individual has been using Differin as directed and isn't seeing improvement after 12 weeks, or if acne worsens, it's best to consult with a healthcare provider. They are able to recommend a different treatment approach, including a different topical medication, oral antibiotics, hormonal therapy (for women), or, in more severe cases, isotretinoin.

What are the bad side effects of Differin?

Differin is generally well-tolerated, but like all medications, has potential side effects. The most common side effects include dryness, redness, irritation, and a burning sensation at the application site. These are typically mild and improve over time as the skin adjusts to the medication. If experiencing severe or persistent side effects, contact a healthcare provider. Since Differin might make the skin more sensitive to the sun, it's important to use sun protection while using the medication.


Can I get Differin at the pharmacy?

In the UK, an individual is able to get Differin from the pharmacy, but it requires a prescription from a healthcare provider.

What is Differin used for?

Differin is used primarily to treat acne. It works by promoting skin cell turnover and has anti-inflammatory properties that help to reduce redness and inflammation associated with acne.

Differin Gel before and after

Individual results with Differin Gel vary, but many people report a noticeable improvement in their acne after 8 to 12 weeks of regular use. Results include a reduction in the number of acne spots, less redness and inflammation, and smoother skin texture.

Remember, if any questions or concerns occur about Differin or any other medication, it's best to consult with a healthcare provider who is able to provide advice tailored to the specific situation.

Buy Differin Online

Please note the information below is intended for general knowledge, please read the patient information leaflet and/or the information provided by a healthcare professional for more specific guidance. This information should not substitute medical advice.

You can buy Differin online from our UK-registered online pharmacy partners. Complete an online consultation form and our system will show you if you are eligible to purchase Differin online. Our pharmacists will then review your order of Differin and dispatch it discreetly to your address.

How to buy Differin online?

You can buy Differin by following the following steps.

  1. Fill out our online consultation form
  2. If you are eligible to purchase Differin you will be shown it as one of your treatment options
  3. Pay online and receive your order to the comfort of your chosen address

Can I get Differin on the NHS?

Whether or not you can get Differin on the NHS is dependent on your local guidelines and eligibility status. It is best to contact your local GP service if you are unsure of whether you can get Differin from the NHS.

Can you get Differin over the counter?

No, you can’t get Differin over the counter without a prescription or consultation. Differin is a regulated medication so all purchases need to have a prescription and/or suitable consultation form completed.

Can I buy Differin online even if I have never taken it before?

A prescribing pharmacist will need to review your consultation form before the medication can be dispatched. One of our partner prescribing pharmacists will review the consultation form and will decide if you are eligible to buy Differin.

Is Differin safe?

If you have been prescribed Differin then it is at the discretion of the prescriber.

However, all medications can potentially have adverse effects and should be taken exactly as prescribed. If you experience any side effects when taking Differin then you should contact a doctor immediately.

Are there any foods that should be avoided when taking Differin?

We recommend you read the patient information leaflet for this product thoroughly before taking the treatment. This is essential to understanding any interactions that can occur and to take the medication safely.

Can I buy Differin from Boots?

It is generally possible to purchase medication, including Differin, from UK pharmacies like Boots. However, I recommend checking the Boots website or contacting Boots directly for the most current and accurate information. Remember to consult with a healthcare professional before starting any new medication.

Can I buy Differin from Superdrug?

If you would like to buy Differin, you will need to check availability on the Superdrug website.

Can I buy Differin from Amazon?

Amazon does not sell medication such as Differin, as they are not a pharmacy service provider. Always check with Amazon to see what they sell.

How long does Differin take to work?

The time it takes for a Differin to work can vary greatly depending on several factors, such as the strength, the individual's age, weight, and overall health, as well as any potential interactions with other medications or substances. Generally, the effects of Differin may be noticeable within the time frame outlined by the prescribing pharmacist. It is important to follow the prescribed dosage and instructions provided by your healthcare professional, and to consult them if you have any concerns or questions about the medication's efficacy or possible side effects.

How effective is Differin?

The effectiveness of Differin can vary significantly depending on various factors, such as the dosage, the condition being treated, the individual's age, weight, and overall health, as well as the presence of any other medications or substances that might interact with it. While some medications may be highly effective for certain individuals and conditions, others might experience a lesser degree of benefit or may require adjustments to the dosage or additional treatments to achieve the desired results.

What are the risks of taking Differin?

At Welzo, we are dedicated to providing our customers with accurate and comprehensive information about medications. We believe that understanding the potential risks and side effects associated with a medication is essential for making informed decisions about your health. This guide outlines some general considerations for assessing the risks of medication and includes references to the National Health Service (NHS) for further information.

  1. Read the Patient Information Leaflet (PIL): Every medication comes with a Patient Information Leaflet, which provides essential details about the drug, its uses, and potential side effects. Be sure to read this leaflet carefully before starting any new medication. The Electronic medicines compendium has a list of patient leaflets. you can visit by heading to
  2. Be aware of potential side effects: All medications have the potential to cause side effects, ranging from mild and short-lived symptoms to more serious, long-lasting issues. It's important to understand the possible side effects of a medication and how to manage them. The NHS has a helpful resource on managing medication side effects, while also speaking to a healthcare professional is important in understanding any potential risks of taking Differin.
  3. Interactions with other medications: Some medications may interact with others, leading to increased side effects or reduced effectiveness. Make sure to inform your healthcare professional about all the medications and supplements you are currently taking. The NHS offers a useful tool for checking potential drug interactions here.
  4. Contraindications and precautions: Certain medical conditions or factors may make it unsafe for you to take a particular medication. Before starting any new medication, inform your healthcare professional about your medical history and any current health issues. The NHS provides more information about contraindications and precautions here.
  5. Appropriate use and dosage: It's crucial to follow the prescribed dosage and instructions for taking a medication to ensure its effectiveness and minimise the risk of side effects. The NHS has a useful guide on using medicines safely here.
  6. Monitoring and follow-up: Some medications require regular monitoring or follow-up appointments with your healthcare professional to ensure their safety and effectiveness. Be sure to schedule and attend these appointments as needed.

Can I buy Differin in the UK?

Yes, you can buy Differin in the UK with a valid prescription and or consultation form. Differin is available in the UK for purchase from local pharmacies with a valid prescription and or consultation and to purchase from Welzo if in stock. It is imperative that you ensure that the pharmacy you are buying the products from is licensed and registered with the General Pharmaceutical Council (GPhC).

Where can I buy Differin?

You can buy Differin online from upon completion of a consultation form and a free review from a prescribing pharmacist.

Are Differin users satisfied with the product?

We have a list of reviews from customers taking Differin at the bottom of this page. For more information of the reviews of Differin head over to for further details.

Can I buy Differin from an online pharmacy?

Yes, you can purchase Differin from an online pharmacy. However, this is dependent on your eligibility for the medication.

How much does Differin cost?

The costs of Differin are listed at the top of the page. Pricing is provided as a reference as treatment options will be shown upon completing the consultation form.

Can I use Differin gel for wrinkles?

Differin gel is a prescription medication and should only be used under the supervision of a healthcare provider. We only prescribe it to treat previously diagnosed acne.

Is Differin the same as retinol?

No, Differin gel is not the same as retinol. Retinol is a type of vitamin A that can be found in over-the-counter skincare products. While retinol can help to improve the appearance of the skin, it is not as potent as prescription retinoids like Differin gel. 

Is this medication suitable for me?

Please get in touch with a doctor if you are unsure what medication is suitable for you. You can also complete our online consultation form to check your eligibility for the product.

How is the medication delivered?

All orders placed before 14:00 from Monday to Friday will be dispatched that day. The orders are sent using 24 Hour Tracked delivery provided by Royal Mail. Items will usually arrive the very next day after the order has been placed. We also provide tracking for your orders to check the status and location of your parcel. All our medication is packaged in plain confidential padded white or brown envelopes. This ensures that your orders are discreet, and the content of the orders will be for your eyes only.

What does Differin do for your skin?

Differin gel contains the active ingredient adapalene, which is a type of retinoid. Retinoids are compounds that are similar to vitamin A and work by helping to renew skin cells and improve the appearance of the skin. Differin gel is applied topically to the skin and works by regulating the skin cell turnover which is usually very high in acne. 

Additionally, some retinoids may also help to reduce the appearance of fine lines and wrinkles.

How long does it take Differin to work?

Results can be visible within two weeks of continuous use. Clinical studies have shown that after 12 weeks of use, patients reported an 87% reduction in acne.

How do I order my medication?

Some products only require an online consultation which approximately takes 1 minute to complete, enabling you to then buy the product. Other products will also require a prescription; in this case, you will need to complete the online consultation, and then one of our partner pharmacy prescribers or doctors will review the online consultation questions and approve the order for delivery if you are eligible to purchase the item.

Can I cancel or return my order?

For non-medicinal products, you are eligible to return the product within 14 days of receipt in the same packaging you received. For medicinal products, you are eligible to cancel the order only until it has been dispatched. From that point forward, you are no longer eligible to return the order.

You have the right to cancel your order for medication up to the point when your medication is dispatched.

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Customer Reviews

Based on 1 review
Izetta Funnell

The professionalism and expertise of's home pharmacy delivery team is impressive and greatly appreciated.