Pancreatic enzyme supplements are essential for individuals experiencing digestive difficulties due to reduced enzyme production by the pancreas. Whether caused by chronic conditions like pancreatitis, cystic fibrosis, pancreatic surgery, or other gastrointestinal disorders, insufficient enzyme secretion can lead to poor nutrient absorption, bloating, diarrhoea, and unintentional weight loss. Supplementing with clinically formulated pancreatic enzymes can help restore proper digestive function by breaking down fats, proteins, and carbohydrates—improving both gastrointestinal comfort and nutritional status. These supplements are often used as part of Pancreatic Enzyme Replacement Therapy (PERT) and are recognised by gastroenterologists and dietitians as a cornerstone in managing Exocrine Pancreatic Insufficiency (EPI). At Welzo, we provide a carefully selected range of high-quality enzyme supplements, backed by science and manufactured to meet rigorous standards for purity and potency.

What Are Pancreatic Enzymes?

Pancreatic enzymes are essential digestive proteins produced by the pancreas that help break down the three main macronutrients:

• Lipase – breaks down fats

• Protease – breaks down proteins

• Amylase – breaks down carbohydrates

In individuals with reduced pancreatic function—known as Exocrine Pancreatic Insufficiency (EPI)—the body cannot absorb enough nutrients from food. This can lead to symptoms such as bloating, gas, oily stools, fatigue, and unintended weight loss.

“Patients with pancreatic insufficiency may be absorbing as little as 50% of their nutrients. Supplemental enzymes can restore proper digestion and improve quality of life.”
— Dr. Stephen Hanauer, Professor of Gastroenterology, Northwestern University

Who Should Consider Pancreatic Enzyme Supplements?

Pancreatic enzyme supplements are clinically recommended for individuals with:

• Chronic pancreatitis

• Cystic fibrosis

• Pancreatic cancer or post-pancreatectomy

• Coeliac disease or Crohn’s disease with malabsorption

• Small Intestinal Bacterial Overgrowth (SIBO)

• Gallbladder removal (cholecystectomy)

They may also be used for general digestive support in cases of unexplained bloating, fat malabsorption, or nutrient deficiencies.

Evidence-Based Benefits

Pancreatic Enzyme Replacement Therapy (PERT) has been shown to:

• Improve fat and protein absorption

• Reduce bloating, diarrhoea, and gas

• Help maintain healthy body weight and reduce malnutrition risk

• Enhance quality of life in individuals with pancreatic and gastrointestinal conditions

A study in Clinical Gastroenterology and Hepatology (2011) demonstrated that PERT significantly improved nutrient absorption and reduced symptoms in patients with EPI after just two weeks of treatment.

Key Ingredients to Look For

Our pancreatic enzyme products are formulated with:

• Porcine-derived pancreatin (standardised amounts of amylase, lipase, and protease)

• Plant-based enzyme blends for vegetarian users

• Enteric-coated capsules to protect enzymes from stomach acid and ensure delivery to the small intestine

• Complementary ingredients such as ox bile, betaine HCl, or probiotics for enhanced digestive synergy