Is Tadalafil safe?

Man standing for medicines

Understand how to use Tadalafil safely.


Tadalafil- A solution to erectile dysfunction

Tadalafil (a generic form of famous brands; Cialis and Adcirca) is becoming increasingly popular in treating erectile dysfunction (ED). It is appealing to people because you don't need to keep it in your pocket and use it before intercourse (like Viagra). Instead, you can take it daily and experience normal bodily functioning throughout the day. It is also available in the form of low dosage pills. Besides the treatment of ED, it is also prescribed to treat pulmonary arterial hypertension (PAH) and benign prostatic hyperplasia (BPH).

You can also use it before sexual activity, and its effects last up to 36 hours. Although it offers some benefits over Viagra, is it completely safe? To have the final say about its safety, you should first know how it acts, its possible side effects, and how they could be minimized to have maximum protection.'


How does it work to treat erectile dysfunction?

Any erectile dysfunction drug should increase blood flow into the muscles of the penis. Like Viagra, Tadalafil works by inhibiting the enzyme phosphodiesterase-5 (PDE5). This hormone breaks the guanosine monophosphate (cGMP) cycle, which is responsible for widening the blood vessels that supply the blood to the penis.

Due to the inhibition of this enzyme, the cGMP stays for a more extended period in your body, causing a prolonged and persistent erection due to relaxing blood vessels and increased blood flow. However, it should be understood that it can't cause sexual stimulation.

To learn more about erectile dysfunction, see our information page here.

What could be the possible side effects?

To understand the safety, you should first understand its possible side effects. For details of side effects, you should consult the leaflet available in the pillbox. Moreover, some side effects may not be noticeable, while others may persist and lead you to the emergency room.

Mild sides effects

These side effects influence 1-2 people out of a hundred. They are primarily dose-dependent, i.e., their severity may increase with increasing dose, and these effects are mainly due to disturbance of blood pressure (BP) and drug interactions. If you notice these symptoms, consult your physician or pharmacist. He may suggest you a change in dose.

These side effects include:

  • Muscle aches
  • Facial redness and flushing
  • Nausea
  • Headaches
  • Stuffy nose
  • Indigestion
  • Abnormal ejaculation
  • Diarrhoea
  • Memory problems

More severe effects

These side effects usually influence one in a thousand people. However, they require emergency care. If you note them, it is advised to stop the medication and consult the doctor immediately.

These effects are:


It is a highly prolonged, persistent, and painful erection. Any erection lasting more than 4 hours should be a cause for concern, and you should immediately consult the doctor. Prolonged erections for up to 36 hours have been reported.

Chest pain

These may happen during sex or after sexual intercourse. Therefore, it is advisable to relax a bit.

Sudden hearing or eyesight issues

Erectile dysfunction medications can increase hearing and eyesight issues due to the disturbance of blood supply to optic and ear nerves. A typical example is the non-arteritic Anterior Ischemic Optic Neuropathy (NAION). Although various other factors, e.g., high Blood pressure, heart diseases, and diabetes, have a role, the use of Tadalafil can exacerbate the situation.

Fits or seizures

Generalized seizures could be noted after taking Tadalafil. In addition, a 2018 study found that it can increase the risk and frequency of attacks and reduce the efficacy of oxcarbazepine, a drug used to treat convulsions and seizures.

Problems with blood flow and blood pressure

Tadalafil and other PDE5 inhibitors relax the blood vessels and cause low blood pressure. It is used to lower blood pressure and pulmonary arterial hypertension. So, consult your healthcare professional if you are taking blood pressure drugs. An earlier study in 2006 found that a single 20 mg tablet can reduce diastolic and systolic blood pressure by 4.8 mmHg.

Severe and sudden allergic reactions

An allergic reaction may cause red spots (hives), reddish patches on the skin, and swelling around the eyes.

When do you need to call emergency medical care?

Whenever you note any of the following symptoms, it is the alarm to call for emergency help.

  • Painful allergic reactions
  • Wheezing
  • Chest tightness and sore throat
  • Trouble breathing
  • Swelling of the throat, mouth, lips, tongue, etc...

Is it safe?

It is safe within safe dosages. The safe dosage is different for different individuals. You may start with a 2.5 mg pill and increase gradually until satisfactory intercourse is achieved. Montorsi and his colleagues undertook an earlier study in 2004 on the safety of Tadalafil. The trial involved 1173 patients of ED for 24 months. It was found that the tolerance and safety of Tadalafil were satisfactory for the majority of the patients. Although milder side effects were reported, only 6.3% of people left the treatment due to adverse effects, and 8.6% noted severe side effects.

A more recent review study in 2017 found that using Tadalafil daily is better than its on-demand use.

So, in general, it could be a safe drug to treat pulmonary hypertension and ED for healthy people. However, for better results, its daily use is recommended. Moreover, you do not need to worry about a missed dose.

Consideration for safe use

Although it is a relatively safe solution to treat symptoms of ED, you can increase the safety by following these guidelines.

  • It usually requires 30-60 minutes to work. So, use it at least 30 minutes before sexual intercourse.
  • The starting dose could be 2.5 mg. However, you can go higher with the consultation of the doctor. Some evidence suggests that grapefruit juice could increase the plasma levels of Tadalafil. So, you can use a reduced dose of grapefruit juice and get the best results.
  • Do not drink alcohol with tadalafil tablets.
  • Note any sudden decrease in blood pressure and respond immediately.

Consult wellness professionals before using it if you take alpha-blockers, recreational drugs, antifungal drugs, and other medications or have HIV.


Tadalafil is a safer choice for ED because it is available in low dosages (as low as 2.5 mg) and can be taken daily. It could also be taken before sexual activity. However, take note of the various possible reactions to the drug.

To learn more about how to order Tadalafil, click here.

You can also learn more about other ED medications here.

Erectile Dysfunction Treatment and Services

  1. Erectile Dysfunction Treatment UK
  2. Buy Viagra online
  3. Buy Sildenafil online
  4. Buy Cialis online
  5. Buy Spedra online
  6. Buy Tadalafil online
  7. Buy Eropid online
  8. Buy Vardenafil online
  9. Erectile Dysfunction Blood Test
  10. Buy Levitra online

Articles on Erectile Dysfunction

  1. Erectile Dysfunction: Symptoms, Causes, Diagnosis, and Treatment
  2. Simple Trick to Cure ED: 7 Simple Steps
  3. Can Diabetes Affect Erectile Dysfunction?
  4. Buy an erectile dysfunction blood test
  5. What's the Difference Between Viagra and Viagra Connect?
  6. Does Viagra work for women?
  7. What is nofap?
  8. Does viagra make you last longer in bed?
  9. Can porn cause erectile dysfunction? Porn-induced erectile dysfunction
  10. The best 15 foods for erectile dysfunction
  11. Where can you buy Viagra?
  12. What's the Average Penis Size?
  13. Does mindfulness improve erections? A step-by-step guide
  14. Alternative treatments for erectile dysfunctions
  15. How long do erections last?
  16. How to cure ED permanently?
  17. Is the penis a muscle?
  18. Is Cialis or Viagra better?
  19. Can taking Viagra cause erectile dysfunction?
  20. Is Viagra safe?
Share article
1 of 4
1 of 4
Get 10% off your first order
Get 10% off your first order

Plus get the inside scoop on our latest content and updates in our monthly newsletter.